Design, synthesis, biological evaluation and molecular modeling investigation of new N'-(2-Thiouracil-5-oyl) hydrazone derivatives as potential anti-breast cancer and …

AAS El-Etrawy, FF Sherbiny - Journal of Molecular Structure, 2021 - Elsevier
hydrazones as versatile precursors combined with thiouracil derivatives for the synthesis of
a variety of biologically … target for anticancer agents, due to its pivotal role in DNA synthesis; …

Synthesis and Biological Evaluation of Some Novel Bis-Thiadiazoles as Antimicrobial and Antitumor Agents

WAMA El-Enany, SM Gomha, W Hussein… - Polycyclic Aromatic …, 2021 - Taylor & Francis
… 2CH 3 , 4Ar-H, and 2 hydrazide NH and 2 hydrazone NH, respectively, in addition to the 10
Ar-H. … Newly synthesized target compounds were also evaluated for their in vitro antifungal

[HTML][HTML] Synthesis, Characterization, and Biological Evaluation of Some Novel Pyrazolo[5,1-b]thiazole Derivatives as Potential Antimicrobial and Anticancer Agents

A Alsayari, AB Muhsinah, YI Asiri, FA Al-Aizari… - Molecules, 2021 - mdpi.com
… the appropriate aromatic aldehyde to afford the corresponding hydrazones 3a,b (Scheme 1).
… All tested compounds except compound 8 showed high antifungal activity against Candida …

Anticancer, antimicrobial activities of quinoline based hydrazone analogues: Synthesis, characterization and molecular docking

KD Katariya, SR Shah, D Reddy - Bioorganic chemistry, 2020 - Elsevier
anticancer agents bendamustine and chlorambucil, revealed that the quinolyl hydrazones
holds promise as a potential anticancer agents. … as well as antifungal activity with MIC value …

Synthesis, structural characterization, and biological evaluation of some hydrazone compounds as potential antioxidant agents

E Başaran, N Haşimi, R Çakmak, E Çınar - Russian Journal of Bioorganic …, 2022 - Springer
… While the hydrazone compounds (II–VIII) synthesized in this study are used for different …
evaluated before. There have been many studies in the literature on antibacterial, antifungal, …

Synthesis, anticancer and antimicrobial evaluation of new pyridyl and thiazolyl clubbed hydrazone scaffolds

MB Muluk, AS Ubale, ST Dhumal… - Synthetic …, 2020 - Taylor & Francis
… and antifungalnew pyridyl and thiazolyl clubbed hydrazone scaffolds starting from an
antitubercular drug, prothionamide. The synthesized hydrazone derivatives were evaluated for …

New piperazine-hydrazone derivatives as potential antimicrobial agents: Synthesis, characterization, biological evaluation, and in silico investigations

YU Cebeci, ÖÖ Batur, H Boulebd - Journal of Molecular Structure, 2023 - Elsevier
… , the synthesis and biological activity of a new series of piperazine-hydrazone derivatives
have … , compounds were synthesized based on antimicrobial and antifungal compounds. The …

[HTML][HTML] Synthesis and biological evaluation of some novel thiazole-based heterocycles as potential anticancer and antimicrobial agents

S Abu-Melha, MM Edrees, HH Salem, NA Kheder… - Molecules, 2019 - mdpi.com
… The development of new antitumor agents represents an … Treatment of hydrazone derivative
3 with the appropriate … On the contrary, all synthesized compounds had no antifungal activity …

Design, synthesis, anti-proliferative, anti-microbial, anti-angiogenic activity and in silico analysis of novel hydrazone derivatives

H Ünver, B Berber, R Demirel… - Anti-Cancer Agents in …, 2019 - ingentaconnect.com
anticandidal derivatives than standard antifungal antibiotics. The QSAR analysis suggested
that the tumor specificity of the hydrazone … SC Synthesis and biological evaluation of Schiff’s …

[HTML][HTML] Synthesis and biological evaluation of thiazolyl-ethylidene hydrazino-thiazole derivatives: a novel heterocyclic system

LA Al-Mutabagani, FM Abdelrazek, SM Gomha… - Applied Sciences, 2021 - mdpi.com
… identifying new lead compounds, notably anticancer drugs [19,… appearance in several clinically
available anticancer drugs, … variable in vitro antibacterial and antifungal activities (Table 1…